“It has not been know exactly how ECT works. It is known that ECT reduces brain activity and raises seizure threshold (makes it less likely to have a seizure). This implies that overall neuronal activity is reduced, so perhaps ECT is inhibiting overactivity in a part of the brain that is driving the depression. That hypothesis is supported by a recent study that uses fMRI scanning to look at brain activity in nine patients with major depression before and after ECT. They found:
A comparison of pre- and posttreatment functional connectivity data in a group of nine patients revealed a significant cluster of voxels in and around the left dorsolateral prefrontal cortical region (Brodmann areas 44, 45, and 46), where the average global functional connectivity was considerably decreased after ECT treatment (P < 0.05, family-wise error-corrected). This decrease in functional connectivity was accompanied by a significant improvement (P < 0.001) in depressive symptoms
Once way to interpret this result is that some patients with major depression have overactive connectivity between that part of the brain that generates the emotion of depression and the part of the brain involved in cognition and concentration. In these patients, therefore, their depressed mood has a significant effect on their thoughts and ability to concentrate. ECT appears to reduce this hyperconnectivity, which should significantly reduce the symptoms of depression.
This is all consistent with prior research on depression, and makes good sense. Still, it’s a small study that needs to be replicated and the whole question further explored.” (via NeuroLogica Blog ).


























































“The standout of this year’s Sundance and among the best films to play at the festival in two decades, “Beasts of the Southern Wild” isn’t an obvious studio-dependent title. Directed by Benh Zeitlin, who wrote the screenplay with Lucy Alibar, the film is a magical realist tale, as well as a hero’s journey, set in a gloriously mythologized part of southern Louisiana nicknamed the Bathtub. There, a 6-year old girl, Hushpuppy (Quvenzhané Wallis, a sensational find), lives in a state of grace and wonder with her hard-boozing father, Wink (Dwight Henry), amid wandering (and later cooked) chickens, stumbling drunks and rampaging creatures.



