Autism finding could lead to simple urine test for the condition

Autism spectrum
Autism spectrum

Children with autism have a different chemical fingerprint in their urine than non-autistic children, according to new research published tomorrow in the print edition of the Journal of Proteome Research.

The researchers behind the study, from Imperial College London and the University of South Australia, suggest that their findings could ultimately lead to a simple urine test to determine whether or not a young child has autism.

Autism affects an estimated one in every 100 people in the UK. People with autism have a range of different symptoms, but they commonly experience problems with communication and social skills, such as understanding other people’s emotions and making conversation and eye contact.

People with autism are also known to suffer from gastrointestinal disorders and they have a different makeup of bacteria in their guts from non-autistic people… The distinctive urinary metabolic fingerprint for autism identified in today’s study could form the basis of a non-invasive test that might help diagnose autism earlier. This would enable autistic children to receive assistance, such as advanced behavioural therapy, earlier in their development than is currently possible.

At present, children are assessed for autism through a lengthy process involving a range of tests that explore the child’s social interaction, communication and imaginative skills.

Early intervention can greatly improve the progress of children with autism but it is currently difficult to establish a firm diagnosis when children are under 18 months of age, although it is likely that changes may occur much earlier than this.

The researchers suggest that their new understanding of the makeup of bacteria in autistic children’s guts could also help scientists to develop treatments to tackle autistic people’s gastrointestinal problems.” (Science Blog)

Depression’s Upside

On the Threshold of Eternity

Wonderful behavioral science writer Jonah Lehrer (Proust Was a Neuroscientist) writes for the New York Times Magazine on the idea that depression may be adaptive. It is not a new idea; I have followed the intriguing literature about possible evolutionary reasons for the persistence of depression ever since I was a psychiatric resident troubled by how readily we in the field want to obliterate any signs of the condition whenever our patients present with it. Some theories have focused on the advantages of resource preservation, given the social isolation, decreased motivation and lessened self-indulgence the depressed person displays. It has also been suggested that the depressive alteration in cognition, in the direction of impaired self-esteem, decreased sense of efficacy and control over one’s circumstances, and pessimism , may actually be more realistic, at least in some circulstances, than the rose-colored glasses with which we usually walk around.

But recent research adds neuropsychological evidence of increased brain activity in depressed patient in regions of the prefrontal cortex associated with problem-solving, proportional to the degree of depression. It is certainly not the whole explanation, as critics counter, because some of the maladaptive impact of depression, including poor self-care, impairment in childrearing, increased susceptibility to other illness, and last but not least suicide, will outweigh the problem-solving advantages it might confer. Furthermore, there are many different kids of depression both in terms of precipitant and symptomatology. At one extreme, a person may become depressed in response to an acute recent loss (or even a future anticipated one); on the other hand, some people can develop either a dense acute depression or a smouldering chronic one without substantial stresses or losses. The imprecisions in both the lay person’s use of the term depression and its more technical clincal utilization muddy the waters in this regard.

Still, it is worth asking why a condition that is so painful and takes such a heavy toll would persist if it were not at least some of the time of some use… and whether, at least some of the time, we do more harm than good in leaping to treat it. Except, of course, the unequivocal good done to the pockets of the shareholders and executives of the pharmaceutical companies, reaping the profits from the explosive growth in antidepressant sales of the last few decades. (New York Times Magazine)

Revising Book on Disorders of the Mind

List of psychiatric medications

FmH readers know of my preoccupation with psychiatric diagnosis, its follies and abuses, about which I am more likely to rant here than any other topic (other than George W. bush and his administration). Today, the American Psychiatric Association posted on the web the details fo the next proposed revision, version V, to the DSM (the Diagnostic and Statistical Manual), which is the ‘bible’ of accepted psychiatric diagnoses and their criteria. DSM-V is currently scheduled to come out in 2013 after a period of public comment on the revisions and several years of field trials. The release date has already been pushed back because of controversy about the proposals and the revision process, some of which is pointed to in this NYTimes.com piece.Several different things happen in these revisions. First, the universe of existing mental illnesses is reparsed and some of the afflicted end up going into different pigeonholes. By and large, this is a trend I welcome, as the new distinctions made, and the old distinctions collapsed and erased, appear to be generally in line with the clinical experience of frontline practitioners like myself who spend all our time actually treating the mentally ill. Some of my pet peeves, like the overdiagnosis of attention deficit disorder, of childhood bipolar disorder, and of posttraumatic stress disorder, may be improved. As Gregory Bateson defined it, information is a “difference that makes a difference”, and some of the refined distinctions here will of course be more useful to psychiatric research than to practice, but by and large I find them meaningful.

However, the other thing that goes on from revision to revision of the DSM is a proliferation of diagnoses, leading to a relentless expansion of the scope and incidence of mental disorders among the population. This is what has been referred to as the medicalization of ‘normal’ human variability and of personality differences. If a broader net is cast and more people are diagnosable with mental disorders, you can imagine some of the consequences, which include the increasing use of medications for more and more benign variations; changes in social stigmatization; insurance reimbursement for various states of distress; and various diminished responsibility defenses in criminal proceedings. More profoundly, we are rewriting the concepts of personal responsibility and autonomy and the balance between free will and determinism.

I already have far too much work to do to welcome such a broader net, but then again I don’t make a fortune on the basis of how many prescriptions are written. (Estimates are that anywhere from 50-70% of those working on the revisions derive substantial income or research funding from the pharmaceutical industry.)

Tonight, because one of their reporters has been a reader of FmH, I was interviewed by the BBC about my impressions about the DSM-V proposals. It remains to be seen whether I gave them any juicy quotes they can use.

The Americanization of Mental Illness

On the Threshold of Eternity

“For more than a generation now, we in the West have aggressively spread our modern knowledge of mental illness around the world. We have done this in the name of science, believing that our approaches reveal the biological basis of psychic suffering and dispel prescientific myths and harmful stigma. There is now good evidence to suggest that in the process of teaching the rest of the world to think like us, we’ve been exporting our Western “symptom repertoire” as well. That is, we’ve been changing not only the treatments but also the expression of mental illness in other cultures. Indeed, a handful of mental-health disorders — depression, post-traumatic stress disorder and anorexia among them — now appear to be spreading across cultures with the speed of contagious diseases. These symptom clusters are becoming the lingua franca of human suffering, replacing indigenous forms of mental illness.” (New York Times Magazine)

Can you really be “addicted” to shopping or using the Internet?

Heroin bottle

“Despite the scientific implausibility of the same disease—addiction—underlying both damaging heroin use and overenthusiasm for World of Warcraft, the concept has run wild in the popular imagination. Our enthusiasm for labeling new forms of addictions seems to have arisen from a perfect storm of pop medicine, pseudo-neuroscience, and misplaced sympathy for the miserable.” — Vaughan Bell (Slate)

Depression’s Evolutionary Roots

Prozac, a selective serotonin reuptake inhibit...

“Two scientists suggest that depression is not a malfunction, but a mental adaptation that brings certain cognitive advantages”. (Scientific American) Evolutionary explanations are appealing, for if depression were not adaptive then why would it be so prevalent across cultures and epochs? Estimates are that between one quarter and one half of the public are clinically depressed at some point in their life.

The suggestion here is that the depressive state, with ruminative thinking, social isolation, and loss of interest in usually pleasurable activities, etc. promotes periods of uninterrupted analytical thinking. This turns some of the therapeutic approaches to depression on their head. Interventions which discourage ruminative thinking might prolong the resolution of a depressive episode. Patients encouraged to amplify on their ruminating, such as journalling, might do better. Perhaps even antidepressant medications might interfere in constructive problem-solving?

I have thought there might be a different evolutionary advantage to depression. After a loss or setback, the depressed person’s lack of energy, motivation and activity act to conserve resources. Their way of thinking about the world, with pessimism and a helpless sense of lack of control over what befalls one, might be more realistic, at least at such a time.

Placebo Response Under Genetic Control

Prozac, a selective serotonin reuptake inhibit...

Monoamine Oxidase A and Catechol-O-Methyltransferase Functional Polymorphisms and the Placebo Response in Major Depressive Disorder: “The placebo response shows pronounced interindividual variability. Placebos are postulated to act through central reward pathways that are modulated by monoamines. Because monoaminergic signaling is under strong genetic control, we hypothesized that common functional polymorphisms modulating monoaminergic tone would be related to degree of improvement during placebo treatment of subjects with major depressive disorder. We examined polymorphisms in genes encoding the catabolic enzymes catechol-O-methyltransferase and monoamine oxidase A. Subjects with monoamine oxidase A G/T polymorphisms (rs6323) coding for the highest activity form of the enzyme (G or G/G) had a significantly lower magnitude of placebo response than those with other genotypes. Subjects with Val158Met catechol-O-methyltransferase polymorphisms coding for a lower-activity form of the enzyme (2 Met alleles) showed a statistical trend toward a lower magnitude of placebo response. These findings support the hypothesis that genetic polymorphisms modulating monoaminergic tone are related to degree of placebo responsiveness in major depressive disorder.” (Journal of Clinical Psychopharmacology)

Some behavioral scientists consider the placebo response to be a nuisance that confounds psychopharmacological research; patients get better even when they do not get the active drug. Some of us, however, feel that the placebo response is a good friend of clinical psychiatry. Some meta-analyses of antidepressant efficacy studies suggest that the medications may not be that effective and that much of the therapeutic response to antidepressants may in fact be ascribable to the placebo response. (The psychiatrist’s role, as a corollary, may be not the art of picking a drug to prescribe but enlisting the individual into a mindset that mobilizes their self-healing capacities.) We already know that depression is related to the reward circuitry in the brain and that genetic susceptibility to depressive disorders relates to polymorphism in the catecholamine system. If the placebo response as well varies with differences in that circuitry, could it be that those patients with lower capacity for the placebo response could also be those patients prone to become depressed int he first place? If we cannot as effectively mobilize their placebo response when they are in the placebo wing of a drug study, perhaps they cannot as effectively bring self-suggestion, affirmation and other coping strategies to bear on the distressing situations in their lives?

Related:

Bitterness: The Next Mental Disorder?

BITTERNESS

No one could accuse the American Psychiatric Association of missing a strain of sourness in the country, or of failing to capitalize on its diagnostic potential. Having floated “Apathy Disorder” as a trial balloon, to see if it might garner enough support for inclusion in the next edition of the Diagnostic and Statistical Manual of Mental Disorders, the world’s diagnostic bible of mental illnesses, the organization has generated untold amounts of publicity and incredulity this week by debating at its convention whether bitterness should become a bona fide mental disorder.” (Psychology Today)

Related:

Bipolar disorder and its biomythology: An interview with David Healy

Cover of "Mania: A Short History of Bipol...

Q: Part of what you describe in your new book Mania: A Short History of Bipolar Disorder is a fair amount of “biomythology” about the illness. What aspects in particular do you have in mind?

A: Biomythology links to biobabble, a term I coined in 1999 to correspond to the widely-used expression psychobabble. Biobabble refers to things like the supposed lowering of serotonin levels and the chemical imbalance that are said to lie at the heart of mood disorders, ADHD, and anxiety disorders. This is as mythical as the supposed alterations of libido that Freudian theory says are at the heart of psychodynamic disorders.

While libido and serotonin are real things, the way these terms were once used by psychoanalysts and by psychopharmacologists now—especially in the way they have seeped into popular culture—bears no relationship to any underlying serotonin level or measurable chemical imbalance or disorder of libido. What’s astonishing is how quickly these terms were taken up by popular culture, and how widely, with so many people now routinely referring their serotonin levels being out of whack when they are feeling wrong or unwell.

structure of serotoninStructure of serotonin

In the case of bipolar disorder the biomyths center on ideas of mood stabilization. But there is no evidence that the drugs stabilize moods. In fact, it is not even clear that it makes sense to talk about a mood center in the brain. A further piece of mythology aimed at keeping people on the drugs is that these are supposedly neuroprotective—but there’s no evidence that this is the case and in fact these drugs can lead to brain damage.

via Psychology Today Blogs.

Oh, I wish I had time right now to comment on this at length. Some great points here, but I think he is throwing babies out with bathwater, Read the entire piece. ..

I find, increasingly, that the practice of psychiatry for me is a difficult balancing act of believing in my role while increasingly disbelieving many of the principles by which our approach is ‘explained’ and justified. Biomythology is a great term for it. The emperor has few clothes…

Ann Bauer: the monster inside my son

“I'm exhausted and hopeless and vaguely hung over because Andrew, who has autism, also has evolved from sweet, dreamy boy to something like a golem: bitter, rampaging, full of rage. It happened no matter how fiercely I loved him or how many therapies I employed.” via Salon.

What is narcissistic personality disorder, and why does everyone seem to have it?

This is the cultural moment of the narcissist. In a New Yorker cartoon, Roz Chast suggests a line of narcissist greeting cards (“Wow! Your Birthday’s Really Close to Mine!”). John Edwards outed himself as one when forced to confess an adulterous affair. (Given his comical vanity, the deceitful way he used his marriage for his advancement, and his self-elevation as an embodiment of the common man while living in a house the size of an arena, it sounds like a pretty good diagnosis.) New York Times critic Alessandra Stanley wrote of journalists who Twitter, “it’s beginning to look more like yet another gateway drug to full-blown media narcissism.” And what other malady could explain the simultaneous phenomena of Blago and the Octomom?” — Emily Yoffe via Slate.

What Doctors (Supposedly) Get Wrong about PTSD

This article in Scientific American by David Dobbs reports on the growing concern that “the concept of post-traumatic stress disorder is itself disordered”. The writer is critical of a culture which “seemed reflexively to view bad memories, nightmares and any other sign of distress as an indicator of PTSD.” To critics like this, the overwhelming incidence of PTSD diagnoses in returning Iraqi veterans is not a reflection of the brutal meaningless horror to which many of the combatants were exposed but of a sissy culture that can no longer suck it up. As usual, the veil of ‘objective’ ‘scientific’ evidence is used to cloak ideological biases.

FmH readers know that I too am critical of the frequency of PTSD diagnosis in modern mental health practice, but I think that is not a problem with the theoretical construct of PTSD but its slapdash application. With respect to domestic PTSD, the problem is one of overzealous and naive clinicians ignoring the diagnostic criteria and, more important, misunderstanding the clinical significance and intent of the diagnosis, labelling with PTSD far too many people who have ever had anything more than a little upsetting or distressing happen to them. Essentially, PTSD is meant to refer to the longterm consequences of either an experience or experiences that are outside the bounds of what the human psyche can endure. Both emotionally and neurobiologically, the capacity of the organism is overwhelmed and the fact of the trauma assumes an overarching and inescapable central role in future information processing, functioning and sense of self. Experience that occurs when the body is flooded with unimaginably high levels of stress hormones, when the nervous system is in the throes of the fight-or-flight response, and when the normal processes for making sense of what we are going through utterly break down are encoded differently in the body and mind, with immeasurable effects. Only someone who did not grasp this at all could misrecognize simple anxiety, depression or adjustment difficulties as PTSD. But it happens all the time, especially in the treatment of depressed women, largely because of do-gooder clinicians’ desires to be politically correct and not be seen as insensitive to their clients’ suffering. Unfortunately, what it mostly does is train these clients to remain lifelong inhabitants of a self-fulfilling inescapable victim role.

The concern, on the other hand, with soldiers returning from the wars in central Asia, is the opposite. All evidence is that PTSD is being underdiagnosed, because of systematic biases within the government and the military to deny the scope of the problem. Articles such as this, and the research that it depicts, should be seen as nothing but a conservative backlash, an effort to blame the victims. If coping with the scope of PTSD is a problem, deny the reality of PTSD. Certainly considerable research suggests that a proportion of soldiers returning from the battle front in bad shape will have shown their resilience, will no longer show a high magnitude of emotional disturbance, and will not warrant a diagnosis of PTSD if reassessed months or years later. Research also suggests that early intervention using a trauma paradigm may do more harm than good, perpetuating the vulnerability of the patient. And most Defense Dept. research on the effects of combat trauma is intended to figure out how to block the stress reaction so that a soldier can remain functional and return to a combat role as soon as possible. But it remains the case that the human nervous system did not evolve to endure the horrors of modern war, and that the indefensibility and anomie of this war in particular, based as it has been entirely on lies, amplifies the intolerability and makes it far less likely that a veteran can find sustaining meaning in the suffering they endured. This will inevitably turn into higher rates of PTSD than among veterans of other wars.

To deny the scale of PTSD in our returning veterans is to be an unquestioning apologist for the untrammelled American imperialist projection of power in lawless aggression. As Dobbs describes it, the PTSD deniers construe us as having a cultural obsession with PTSD which embodies “a prolonged failure to contextualize and accept our own collective aggression.” What horse manure. Our cultural neurosis, rather, lies in the unquestioning acceptance of suggestions like Dobbs’ that we should mindlessly embrace such aggression as natural. This was the neurosis that made it possible to elect Bush and his handlers to enact an administration that set about violating every supposed principle of our democracy and our humanity. I know we are not supposed to draw this particular analogy, but this brand of PTSD denial strikes me as akin to nothing as much as Holocaust denial. Via Scientific American.

‘Grisi Siknis’ outbreak grips indigenous towns in Nicaragua

Hans Baldung Grien: Witches.
Hans Baldung Grien: Witches

A team of traditional indigenous healers and regional health authorities from the North Atlantic Autonomous Region (RAAN) trekked out to visit three rural Miskito communities along the Río Coco on Tuesday to investigate reports of an outbreak of a mysterious collective hysteria, known as “grisi siknis,” or “crazy sickness.”

Centuriano Knight, the regional health coordinator for the RAAN, told The Nica Tim es yesterday in a phone interview that 34 people have reportedly fallen ill with grisi siknis in the river community of Santa Fe, seven people in the nearby community of Esperanza and two in the neighboring community of San Carlos. The outbreak of grisi siknis, which has no scientific explanation, is the largest case of collective hysteria since a massive outbreak in the RAAN community of Raití in 2003.

Though doctors, anthropologists and sociologists have all studied previous cases, no one has been able to explain the phenomena, Knight said. Traditional healers and witches have explained the mysterious illness with different theories ranging from a curse to incomplete witchcraft.

The strange illness apparently affects young people more than old, putting people in a strange trance and apparently giving them super-human strength, according to Knight and other witnesses.” via The Tico Times.

Perhaps because I was a student of cross-cultural studies before I became a psychiatrist, these reports of indigenous illnesses or culture-bound syndromes have always fascinated me. I used to teach a class on them to medical students, which was pure entertainment as far as I was (and, I hope, many of the students were) concerned. Because psychiatric illnesses are as much social constructs as biological realities, a culture-specific syndrome is in a real sense culture-specific. That is why it makes so much more sense that it be dealt with by indigenous practitioners rather than a WHO swat team. Of course, when I moved into psychiatry, I felt I was still utilizing my skills in cross-cultural communication, as every interpersonal interaction is in a sense cross-cultural, if you take my meaning. Thus, every episode of emotional distress is in a sense a culture-bound syndrome, despite what DSM-IV or functional MRI studies might tell you.

Students Stand When Called Upon, and When Not

“The children in Ms. Brown’s class, and in some others at Marine Elementary School and additional schools nearby, are using a type of adjustable-height school desk, allowing pupils to stand while they work, that Ms. Brown designed with the help of a local ergonomic furniture company two years ago. The stand-up desk’s popularity with children and teachers spread by word of mouth from this small town to schools in Wisconsin, across the St. Croix River. Now orders for the desks are being filled for districts from North Carolina to California.” via NYTimes.

Could this be all it might take to stem the tide of tarring and feathering a significant fraction of American gradeschoolers with the ADHD label? (As readers of FmH know, I think this is one of the greatest travesties of modern psychodiagnosis.)

Protein reverses Alzheimer’s brain damage

Brain-derived neurotrophic factor
BDNF

“Injections of a natural growth factor into the brains of mice, rats and monkeys offers hope of preventing or reversing the earliest impacts of Alzheimer’s disease on memory. The benefits arose even in animals whose brains contained the hallmark plaques that clog up the brains of patients.

By delivering brain-derived neurotrophic factor (BDNF) directly into the entorhinal cortex and hippocampus, the parts of the brain where memories are formed then consolidated, the researchers successfully tackled damage exactly where Alzheimer’s strikes first…” via New Scientist.

Is it really bad to be sad?

“…Misery is inconvenient, unpleasant, and in a society where personal happiness is prized above all else, there is little tolerance for wallowing in despair. Especially now we’ve got drugs for it. …So it’s no surprise that more and more people are taking them.

But is this really such a good idea? A growing number of cautionary voices from the world of mental health research are saying it isn’t. They fear that the increasing tendency to treat normal sadness as if it were a disease is playing fast and loose with a crucial part of our biology. Sadness, they argue, serves an evolutionary purpose – and if we lose it, we lose out.

“When you find something this deeply in us biologically, you presume that it was selected because it had some advantage, otherwise we wouldn’t have been burdened with it,” says Jerome Wakefield, a clinical social worker at New York University and co-author of The Loss of Sadness: How psychiatry transformed normal sorrow into depressive disorder (with Allan Horwitz, Oxford University Press, 2007). “We’re fooling around with part of our biological make-up.”

Perhaps, then, it is time to embrace our miserable side. Yet many psychiatrists insist not. Sadness has a nasty habit of turning into depression, they warn. Even when people are sad for good reason, they should be allowed to take drugs to make themselves feel better if that’s what they want.

So who is right? Is sadness something we can live without or is it a crucial part of the human condition?

…there are lots of ideas about why our propensity to feel sad might have evolved. It may be a self-protection strategy, as it seems to be among other primates that show signs of sadness. …it helps us learn from our mistakes. …even full-blown depression may save us from the effects of long-term stress. Without taking time out to reflect, he says, “you might stay in a state of chronic stress until you’re exhausted or dead”. …By acting sad, we tell other community members that we need support….Then there is the notion that creativity is connected to dark moods. …There is also evidence that too much happiness can be bad for your career…” (More)

via New Scientist.

Posting articles on this theme is, readers may have noticed, a recurrent event here on FmH. I began to be introduced to this notion, that depression might serve a useful purpose and that we had to rethink our knee-jerk readiness to vanquish it (and normal sadness as well, which is difficult to disentangle from pathological depression) whenever we encountered it, early in my career. I think it has fundamentally informed my skepticism about the way we organize and administer psychiatric services in this society. In addition, there are concerns that too readily resorting to antidepressant therapy may reinforce future propensity for depressive reactions and need for medication (which I’m sure will please the pharmaceutical industry to hear). I have always said that getting people off of medications, or refraining from prescribing them, are equally important functions of a psychopharmacologist as is prescribing astutely.

High Caffeine Intake Linked To Hallucination Proneness

Chemical structure of Caffeine.

“High caffeine consumption could be linked to a greater tendency to hallucinate, a new research study suggests.

People with a higher caffeine intake, from sources such as coffee, tea and caffeinated energy drinks, are more likely to report hallucinatory experiences such as hearing voices and seeing things that are not there, according to the Durham University study.

‘High caffeine users’ – those who consumed more than the equivalent of seven cups of instant coffee a day – were three times more likely to have heard a person’s voice when there was no one there compared with ‘low caffeine users’ who consumed less than the equivalent of one cup of instant coffee a day.”

via Science Daily.