Day: January 13, 2018

The Neurological Disorders in Alice in Wonderland

“Now I’m opening out like the largest telescope that ever was! Good-bye, feet!” (for when she looked down at her feet, they seemed to be almost out of sight, they were getting so far off).”

‘…The moment Alice arrives in Wonderland, she goes through a series of strange metamorphic changes, becoming larger or smaller after ingesting certain foods and liquids. These sensations are also experienced by individuals with a certain medical condition termed Alice in Wonderland syndrome (AIWS).

AIWS was first described in 1955 by a British psychiatrist Dr. John Todd, who noticed that many of his younger patients experienced distortions in the size of objects or body parts (metamorphopsia) as a result of their migraines. He noted a strong association between these symptoms and migraines, and determined that AIWS may constitute a rare ‘migraine variant’. In fact, Lewis Carroll himself is reported to have suffered from migraines and manifested his experiences in his writing….’

Via Neuroscience News

Does an Exploding Brain Network Cause Chronic Pain?

Explosive Stimulation (ES):

‘In ES, a small stimulus can lead to a dramatic synchronized reaction in the network, as can happen with a power grid failure (that rapidly turns things off) or a seizure (that rapidly turns things on). This phenomenon was, until recently, studied in physics rather than medicine. Researchers say it’s a promising avenue to explore in the continued quest to determine how a person develops fibromyalgia.

“As opposed to the normal process of gradually linking up different centers in the brain after a stimulus, chronic pain patients have conditions that predispose them to linking up in an abrupt, explosive manner,” says first author UnCheol Lee, Ph.D., a physicist and assistant professor of anesthesiology at Michigan Medicine. These conditions are similar to other networks that undergo ES, including power grids, Lee says….’

Via Neuroscience News