“Why human cancer is not more frequent remains a mystery, given our trillions of susceptible cells, each with many genes subject to mutations that could ignite uncontrolled cell proliferation. One intuitive concept — which has been in the spotlight for decades — is that normal cells can somehow perceive and arrest aberrant cycles of cell division that are triggered by cancer-promoting (oncogenic) stimuli, such as the inappropriate activation of oncogenes. But how cells might do so remains elusive.” (Scienceweek)