Engineered Insanity

A Gallery of Wonderfully Useless Complexity: “Not content to leave his devices in the realm of the two-dimensional, many subsequent inventors and tinkerers have created working ‘Rube Goldberg’ machines whose complexity far exceeds anything the cartoonist ever envisioned.

In this gallery, we bring you some recent examples of Goldberg-inspired engineering madness, including several from the recent Rube Goldberg contest, an annual competition held at Purdue University.” (Wired News)

Prescription Ecstasy and Other Pipe Dreams

“Can you picture yourself walking into the neighborhood pharmacy with prescriptions for ecstasy (MDMA) and psilocybin?

If MAPS (Multidisciplinary Association of Psychedelic Studies) has its way, the days of prescription psychedelics may not be too far away. For those who know the history of psychedelic research, this eventuality has been a long time coming. But others — who may only be familiar with the intense emotions and activities around the “War On Drugs” over the past several decades — may be surprised to learn how much progress MAPS has made.” (10 Zen Monkeys)

Advice from an ER doctor to drug seekers

Thanks to walker for pointing me to this diatribe from Craigslist. It is clear, despite his/her disclaimers toward the bottom of the passage, that the ER doctor is very angry with this class of patients. But clean up the language a bit and it is something that ought to be posted on the ER door as an open letter.

How to impeach Gonzales

The icing is Iglesias: “Congress could and should impeach Alberto Gonzales. One ground for doing so, as I have previously suggested (subscription required), is the attorney general’s amnesiac prevarication in his testimony before the Senate and the House. But if Congress wants more, it need look no further than the firing of David Iglesias, former U.S. attorney in New Mexico. The evidence uncovered in Gonzales’ Senate and House testimony demonstrates that he fired Iglesias not because of a policy disagreement or a management failure, but because Iglesias would not misuse the power of the Department of Justice in the service of the Republican Party. To fire a U.S. attorney for refusing to abuse his power is the essence of an impeachable offense.” — Law professor Frank Bowman (Slate)

Row over Scientology video

“The battleground is YouTube and Scientology’s weapon is a clip of me losing it in the ‘Mind Control’ section of a gruesome exhibition. Scientology has fought many battles to keep its secrets off the web, now they are using it to attack my investigation into them. Scientology has prepared an attack video, and they have shown the Scientology v Sweeney shouting match to anyone who would watch it.” — BBC reporter John Sweeney [via walker]

Jerry Falwell’s hit parade.

Timothy Noah in Slate Magazine: “For 20 years, evangelicals have chided the mainstream media for treating Falwell’s ghastly pronouncements as news; Falwell, they often confide in private, ceased being a significant figure well before he left his signature political organization, the Moral Majority, in 1987. If so, someone forgot to tell Sen. John McCain, R.-Ariz., who as a presidential candidate in 2000 condemned Falwell’s intolerance (‘The political tactics of division and slander are not our values, they are corrupting influences on religion and politics, and those who practice them in the name of religion or in the name of the Republican Party or in the name of America shame our faith, our party and our country’) but last year, as a presidential candidate positioning for 2008, made peace with Falwell and gave a commencement address (‘We have nothing to fear from each other’) to the 2006 graduating class at Falwell’s Liberty University. On news of Falwell’s death, McCain said in a statement, ‘Dr. Falwell was a man of distinguished accomplishment who devoted his life to serving his faith and country.’ Nonsense. He was a bigot, a reactionary, a liar, and a fool. Herewith, a Falwell sampler…”

Gonzales Pressed Ailing Ashcroft on Spy Plan, Aide Says – New York Times

In his testimony before the Senate Judiciary Committee, James Comey, former assistant to Attorney General John Ashcroft, describes Alberto Gonzales and Andrew Card rushing to the critically ill Ashcroft’s hospital bedside in March 2004 to pressure him to override Comey’s refusal to reauthorize the secret warrantless domestic surveillance program before its expiration the following day.

“The hospital visit by Mr. Gonzales and Andrew H. Card Jr., who was then White House chief of staff, has been disclosed before, but never in such dramatic, personal detail. Mr. Comey’s account offered a rare and titillating glimpse of a Washington power struggle, complete with a late-night showdown in the White House after a dramatic encounter in a darkened hospital room — in short, elements of a potboiler paperback novel.” (New York Times )

Understanding Empathy

Can You Feel My Pain? “Is shared experience really necessary for a physician to understand or treat a patient? I wonder. After all, who would argue that a cardiologist would be more competent if he had had his own heart attack, or an oncologist more effective if he had had a brush with cancer?” — Richard Friedman MD (New York Times )

Is the "Five-Second Rule" a Myth?

“Harold McGee, also known as the New York Times’ “Curious Cook,” has an article about a new paper from a Clemson University research group led by Paul Dawson on the validity of the “five-second rule” — the old adage that if you drop food on the floor but pick it up within five seconds, it’s okay to eat it. According to a 2003 survey conducted by Jillian Clarke (a high-school intern at the University of Illinois who later won an Ig Nobel Prize for her research), more than 50% of adult men and 70% of adult women knew of the five-second rule, and many said they followed it. Now the Clemson researchers have gathered data to assess its validity once and for all. The results?” [read on] (Freakonomics Blog via walker)

The researchers’ basis for determining if the dropped food is safe to eat depends on ascertaining what bacterial load they pick up from a dirty surface after various intervals. But that does not address the likelihood that the added bacterial load is probably an infinitesimal addition to the daily bacterial load to which we are exposed already, from the same varieties of microbes, even if we never eat a piece of dropped food. More important, although I am not a bacteriologist or an immunologist, I seem to recall an argument that exposure to dirt should be considered akin to an inoculation, invigorating the immune system, and that an obsession with cleanliness may actually leave a person in immunological jeopardy when the time comes to defend oneself. At least that’s my reasoning when I eat something I’ve dropped…and I utilize something more like a thirty-second rule.

Study: Vitamins tied to prostate cancer

A study of approx. 300,000 men revealed the correlation. “Heavy multivitamin users were almost twice as likely to get fatal prostate cancer as men who never took the pills, concludes the study in Wednesday’s Journal of the
National Cancer Institute
. Overall, the researchers found no link between multivitamin use and early-stage prostate cancer. The researchers speculate that perhaps high-dose vitamins had little effect until a tumor appeared, and then could spur its growth.”

Psychiatrists, Children and Drug Industry’s Role

New York Times exposé: “Doctors… maintain that payments from drug companies do not influence what they prescribe for patients.

But the intersection of money and medicine, and its effect on the well-being of patients, has become one of the most contentious issues in health care. Nowhere is that more true than in psychiatry, where increasing payments to doctors have coincided with the growing use in children of a relatively new class of drugs known as atypical antipsychotics.

These best-selling drugs, including Risperdal, Seroquel, Zyprexa, Abilify and Geodon, are now being prescribed to more than half a million children in the United States to help parents deal with behavior problems despite profound risks and almost no approved uses for minors.”

Self-Nonmedication

Bruce Stutz, in the New York Times Magazine, gives a first-person account of his struggles to get off an antidepressant after treated with it. He speculates on whether these drugs have more costs than benefits:

“Ron Duman told me about one way that scientists try to test the effectiveness of a given antidepressant in the lab. Put a laboratory rat into a beaker of water and see how long it struggles to get out. When it stops, remove it from the beaker and treat it with the drug. Repeat the test. If it struggles for a significantly longer time than before, the drug is considered to have antidepressant potential.

Is this ability to keep us going altogether good? As Rosenbaum pointed out to me, people under stress can do great harm not only to themselves but also to those around them parents to their children, couples to each other. But when does reliance on a drug keep us from seeking ways to resolve the causes of stress? General practitioners, not mental-health specialists, write most of the prescriptions for antidepressants. For most doctors and psychiatrists, drugs, not therapy, have become the first line of defense. Only some 20 percent of people prescribed an antidepressant ever have even a single follow-up appointment.”

Self-Nonmedication

Bruce Stutz, in the New York Times Magazine, gives a first-person account of his struggles to get off an antidepressant after treated with it. He speculates on whether these drugs have more costs than benefits:

“Ron Duman told me about one way that scientists try to test the effectiveness of a given antidepressant in the lab. Put a laboratory rat into a beaker of water and see how long it struggles to get out. When it stops, remove it from the beaker and treat it with the drug. Repeat the test. If it struggles for a significantly longer time than before, the drug is considered to have antidepressant potential.

Is this ability to keep us going altogether good? As Rosenbaum pointed out to me, people under stress can do great harm not only to themselves but also to those around them parents to their children, couples to each other. But when does reliance on a drug keep us from seeking ways to resolve the causes of stress? General practitioners, not mental-health specialists, write most of the prescriptions for antidepressants. For most doctors and psychiatrists, drugs, not therapy, have become the first line of defense. Only some 20 percent of people prescribed an antidepressant ever have even a single follow-up appointment.”

FREE Bullshit Deflector!

“The “Bullshit Protector” flaps are a great way to protect yourself from GOP or punditry bullshit and spin, when spewed by the likes of George W. Bush, Rush Limbaugh, or even your local home-grown GOP wingnuts. It was inspired by Bill Moyer, a 73 year old vet, who was seen wearing “Bullshit Protector” flaps over his ears while Bush addressed the Veterans of Foreign Wars in Salt Lake City, Utah.” Download and cut out yours here. //www.wiseass.org/images/bsprotect.jpg' cannot be displayed]

Discardia

“Discardia is a new holiday.

Why do we need a new holiday?

Well, not exactly need, not as such, but this is a very good holiday. It doesn’t involve obligations or expense or overblown expectations of specialness. It does not require you to interact with people whom you do not wish to interact with. In fact, it doesn’t require you to do anything.

Okay, that doesn’t sound too bad. When is it?

The exact days vary. It takes place in the time between the Solstices & Equinoxes and their following new moons. Sometimes it’s short and sometimes it’s long.

Odd. So what is it a celebration of?

Nothing.

What?

Discardia is celebrated by getting rid of stuff and ideas you no longer need. It’s about letting go, abdicating from obligation and guilt, being true to the self you are now. Discardia is the time to get rid of things that no longer add value to your life, shed bad habits, let go of emotional baggage and generally lighten your load.” (Metagrrrl)

The first time I saw this, I read it as Discordia. Now that miight be a holiday I would celebrate wholeheartedly.

Banksy Was Here

The invisible man of graffiti art: “The British graffiti artist Banksy likes pizza, though his preference in toppings cannot be definitively ascertained. He has a gold tooth. He has a silver tooth. He has a silver earring. He’s an anarchist environmentalist who travels by chauffeured S.U.V. He was born in 1978, or 1974, in Bristol, England—no, Yate. The son of a butcher and a housewife, or a delivery driver and a hospital worker, he’s fat, he’s skinny, he’s an introverted workhorse, he’s a breeze-shooting exhibitionist given to drinking pint after pint of stout. For a while now, Banksy has lived in London: if not in Shoreditch, then in Hoxton. Joel Unangst, who had the nearly unprecedented experience of meeting Banksy last year, in Los Angeles, when the artist rented a warehouse from him for an exhibition, can confirm that Banksy often dresses in a T-shirt, shorts, and sneakers. When Unangst is asked what adorns the T-shirts, he will allow, before fretting that he has revealed too much already, that they are covered with smudges of white paint.” (The New Yorker)

Dangerous books for boys (and girls and men and women)

On Boing Boing: “Already a huge hit in the UK, The Dangerous Book for Boys, by Conn Iggulden and Hal Iggulden, is taking the US by storm. The first print run of 80,000 has been supplemented by a second order for 300,000 copies.

While the book is beautifully produced and entertaining, it really doesn’t contain any risky projects that the title and nostalgic design suggest. I can’t blame them — the authors and publisher would open themselves up to lawsuits if they included potentially dangerous projects in the book.

…But “dangerous” books are available, if you want them. Some are reprints of old books now in the public domain, others can be picked up used or downloaded on P2P networks, and some are still being published today by brave authors and publishers.

Here are a few of my favorites…”

Newest Retirement Strategy?

//lifehacker.com/assets/resources/2007/05/stamp.jpg' cannot be displayed] Buy the new ‘forever postage stamps’ now but save them. They cost 41 cents apiece but the USPS promises they will be good for first class postage no matter how high it goes. One Lifehacker reader says that a postal worker gave him this advice when he went to buy stamps this week (the first class rate goes up to 41 cents as of next Monday, 5/14). Of course, the USPS may be persuading us all to sink our savings into postage stamps because they know something about the impending obsolescence of snail mail that we don’t.

DSM-IV and ICD-10 Diagnostic Codes

“Have you ever wondered what your doctor has written in your records? Sure, you can ask. But, such questions might slip your mind in the limited time of a visit. Or, you may not feel comfortable. If you have ever received a carbon copy form your doctor filled out (e.g., to request lab work) you may have seen cryptic codes with check marks next to them. Now you won’t have to wonder what your doctor is recording about you, like I did for weeks until I finally looked it up.

Table 1 : Codes for Mood Disorders

Table 2 : Codes for Substance Induced Mood Disorders

Table 3 : Code Extensions for Severity/Psychotic Features/Remission Specifiers” (A Silver Lining)

Phones studied as attack detector

“Homeland Security officials are looking into outfitting cellphones with detectors that would alert emergency responders to radiological isotopes, toxic chemicals and biological agents such as anthrax.

‘If it’s successful, it’ll change the way chemical, biological and radiation detection is done,’ says Rolf Dietrich, deputy director of the Homeland Security Advanced Research Projects Agency, which invests in high-tech solutions to secure the nation against terrorist attacks. ‘It’s a really, really neat thing.'” (USAToday)

Top 10 Body Hacks

From Lifehacker, how to:

  1. Hold your breath longer
  2. Cure warts with duct tape
  3. Stop brain freeze with your tongue
  4. Scratch your leg to make it to the loo
  5. Power use your ears
  6. Free your mind under a high ceiling
  7. Think while you sleep
  8. Cure hiccups with water
  9. Whistle with two fingers
  10. Tell if someone’s lying

A Scandal That Keeps Growing

New York Times editorial: “It is long past time for President Bush to fire Mr. Gonzales. But Congress, especially the Republicans who have dared confront the White House on this issue, should not be satisfied with that. There are strong indications that the purge was ordered out of the White House, involving at the very least the former counsel, Harriet Miers, and Karl Rove. It is the duty of Congress to compel them and other officials to finally tell the truth to the American people.”

Phones studied as attack detector

“Homeland Security officials are looking into outfitting cellphones with detectors that would alert emergency responders to radiological isotopes, toxic chemicals and biological agents such as anthrax.

‘If it’s successful, it’ll change the way chemical, biological and radiation detection is done,’ says Rolf Dietrich, deputy director of the Homeland Security Advanced Research Projects Agency, which invests in high-tech solutions to secure the nation against terrorist attacks. ‘It’s a really, really neat thing.'” (USAToday)

Monitor’s flicker reveals data on screen

This one is from several years ago — “Reflected and diffuse light from an obscured computer monitor can still be used to reconstruct what is on its screen, say UK researchers. The technique could be used to spy on computers through an office window, for example, even if the monitor was not facing the window.” (New Scientist) The system only works for CRTs, so your laptops and flat panel displays are safe. It was also thought that flat panels were safe from Van Eck phreaking, in which images can be reconstructed by tuning in to the radio coils in CRTs. But the same researcher from the earlier result, Cambridge University’s Marcus Kuhn, has reconstructed LCD images by tuning in to radio transmissions from the video cables carrying the signal to the display. (New Scientist via abby)

Native American DNA found in UK

“Genetic analysis turned up two white British women with a DNA signature characteristic of American Indians. An Oxford scientist said it was extremely unusual to find these DNA lineages in Britons with no previous knowledge of Native American ancestry.

Indigenous Americans were brought over to the UK as early as the 1500s. Many were brought over as curiosities; but others travelled here in delegations during the 18th Century to petition the British imperial government over trade or protection from other tribes.” (BBC)

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Light Bulb Lunacy?

Admittedly, this is from Fox News; so is it truly worrisome or their typical reactionary smear tactics?

“How much money does it take to screw in a compact fluorescent lightbulb? About $4.28 for the bulb and labor — unless you break the bulb. Then you, like Brandy Bridges of Ellsworth, Maine, could be looking at a cost of about $2,004.28, which doesn’t include the costs of frayed nerves and risks to health.

…Aware that CFLs contain potentially hazardous substances, Bridges called her local Home Depot for advice. The store told her that the CFL contained mercury and that she should call the Poison Control hotline, which in turn directed her to the Maine Department of Environmental Protection.

The DEP sent a specialist to Bridges’ house to test for mercury contamination. The specialist found mercury levels in the bedroom in excess of six times the state’s “safe” level for mercury contamination of 300 billionths of a gram per cubic meter.” [thanks, Carol]

A Subway Named Mobius

1950 short story by astronomer A.J. Deutsch:

“The principles of connectivity state that as a system makes more connections to other parts of itself, the connectivity of that system increases in an exponential fashion to staggering levels. The subway under New York City had been growing in complexity for years. It was so complex, in fact, that the best mathematicians could not calculate its connectivity.

Then the first train disappeared. The system was closed, so it couldn’t have gone anywhere, but when all the trains were pulled, they still couldn’t find it. The searchers would see a red light, wait curiously, and hear a train passing in the distance, sometimes so close that it appeared to be just around the next bend. Where was the train? What happened to the passengers? Professor Tudor has a theory…”

Does anyone else remember this story, which I read in the ’50’s and which has stuck with me ever since… ?

Also:

Mathematical Fiction Homepage

“Do you like fiction and mathematics? Are you looking for a book or story that might be useful for the students in your math class? Are you interested in what our society thinks about mathematicians? Then you’ve come to the right place…
The Mathematical Fiction Homepage is my attempt to collect information about all significant references to mathematics in fiction. “

And:

Moebius 17

If you can make heads or tails of it:

“Two writers are bombing a train. Eventually, drawing the highlights, they are suprised by the security staff. They are being chased but finally manage to escape. One of the two writers, starred by Johannes Benecke, decides not to give up until he gets “a fuckin’ picture of his fuckin’ train”. Trying to get a picture of his rolling canvas, he has to face a labyrinth of subway lines crossing each other, connections, quotations, fantastic observations, and paradoxical indications. However, Train No. 17 is missing inside the underground system. The Public Transport are looking for the disappeared train as well. The special Graffiti commission, special forces, and computer experts begin to chase. Parallelly, the chairman of the Public Transport, Himmel, is being accused of corruption while building a new cross connection. This is not by chance. In real life, Himmel’s name is Arno Funke who became Germany’s most sympathetic blackmailer of department stores using the alias “Dagobert”. Is he once again trying to escape in the underground with millions? Jörg Gudzuhn does not play a role in here. However, the actor starred already in 1994 as a commissioner searching the “Phantom” Dagobert. In 1991, he starred as a professor looking for a ghost train in Berlin in the movie “Moebius”. The current Moebius conspirancy started in 1997, when Frank Lämmer watched the Argentinian adaption of the story. Since that time, he has been on the “Moebius-stripe”. This differentially theoretical phenomenon, named after its discoverer A.F.Moebius, was not only engraved by the Dutch artist M.C. Escher in wood but has also animated the writer Esher to follow the nine ants of his namesake. Together with Jo Preußler he started the securing of evidence in 2002. After a wooden subway got cinematically lost inside the subway system of Buenos Aires, it is now up to No. 17. Both of the two Berlin film-makers have realized that one cannot get anywhere with this paradox using the five senses and a classical conservative world view. Therefore, they grab together with a crew of writers the motif of the short story “A Subway Named Moebius” by A. J. Deutsch(1950) and actualize the following idea: Two writers are bombing a train …”

Not cellular transmissions after all?

Experts may have found what’s bugging the bees: “A fungus that caused widespread loss of bee colonies in Europe and Asia may be playing a crucial role in the mysterious phenomenon known as Colony Collapse Disorder that is wiping out bees across the United States, UC San Francisco researchers said Wednesday.

Researchers have been struggling for months to explain the disorder, and the new findings provide the first solid evidence pointing to a potential cause.

But the results are ‘highly preliminary’ and are from only a few hives from Le Grand in Merced County, UCSF biochemist Joe DeRisi said. ‘We don’t want to give anybody the impression that this thing has been solved.'” (LA Times)

A Case Against Cheney

Richard Cohen: “Kucinich is an odd guy for whom the killer appellation ‘perennial presidential candidate’ is lethally applied. But he is on to something here. It is easy enough to ad hominize him to the margins — ya know, the skinny guy among the ‘real’ presidential candidates — but at a given moment, and this is one, he’s the only one on that stage who articulates a genuine sense of betrayal. He is not out merely to win the nomination but to hold the Bush administration — particularly Cheney — accountable. In this he will fail. What Cheney has done is not impeachable. It is merely unforgivable.” (Washington Post op-ed)

Guess what movie may make you sick…

Babel is immensely popular in Japan, in part thanks to a memorable and powerful role by Japanese actress Rinko Kikuchi. But, reminiscent of a memorable incident caused by an episode of the Pokemon cartoon series a decade ago, a number of Japanese have been sickened by a one-minute scene in Babel involving a visit to a club in which strobe lights flash for about a minute. The phenomenon has prompted the posting of a health advisory on the distributor’s website and on posters at theatres showing the film. (Yahoo! News) While strobe-induced seizure activity is a well-known phenomenon in patients with preexisting epilepsy, it is quite rare. In contrast, this has some of the hallmarks of communicable hysteria. It is a little different from the Pokemon incident, which affected viewers simultaneously without forewarning, and which probably attracted a much larger viewing population.

World’s cities step up pace of life

“Pedestrians in Singapore were crowned the world’s fastest movers, walking 30 percent faster than they did in the early 1990s, and in China, the pace of life in Guangzhou has increased by more than 20 percent.

Copenhagen and Madrid were the fastest European cities, beating Paris and London. And despite its reputation as ‘the city that never sleeps,’ New York ranked only eighth in the pace race, behind Dublin and Berlin.” (Yahoo! News)

R.I.P. Bobby Pickett

//www.recordresearch.com/Album_Photos/images/Pickett_%20Bobby%20Boris.jpg' cannot be displayed]

“Bobby (Boris) Pickett, whose Boris Karloff impression propelled the Halloween novelty song “Monster Mash” to the top of the charts in 1962, making him one of pop music’s most enduring one-hit wonders, died Wednesday in Los Angeles. He was 69. His longtime manager, Stuart Hersh, said the cause was leukemia.

Mr. Pickett’s multimillion-selling single — with the indelible chorus “He did the monster mash, it was a graveyard smash” — hit the charts three times: on its original release in 1962, when it reached No. 1, and in 1970 and 1973. Mr. Pickett’s Karloff impression was forged in Somerville, Mass., where as a 9-year-old he watched horror films in a theater managed by his father. He later made it part of his act when he began performing in Hollywood nightclubs in 1959.

Mr. Pickett also did the voice when performing with his band the Cordials. A bandmate, Lenny Capizzi, persuaded Mr. Pickett to do a song featuring the Karloff impression, and “Monster Mash” was born.” (New York Times )

New car smell is bad for you

Is nothing sacred??!! “That ‘new car smell’ can be hazardous to your health, The Ecology Center, a Berkeley, Calif., environmental group said. The Ecology Center said toxic chemicals such as bromine, chlorine and lead found in cars’ interiors give off harmful fumes for three years, the Chicago Tribune reported.

The group listed the 10 least toxic vehicles in a report: the Acura RDX; BMW X3; Chevrolet Cobalt; Chrysler PT Cruiser; Honda Odyssey; Nissan Frontier; Suzuki Aerio wagon; Toyota Matrix; and Volvo S40 and V50.

The 10 worst vehicles were: the Chevy Aveo, Express and Silverado; Hyundai Accent; Kio Rio and Spectra; Nissan Versa; Scion xB; Subaru Forester; and Suzuki Forenza.” (Earthtimes)

Chemotherapy Fog Is No Longer Ignored as Illusion

“Chemo brain is part of the language now… [A]ttitudes are changing as a result of a flurry of research and new attention to the after-effects of life-saving treatment. There is now widespread acknowledgment that patients with cognitive symptoms are not imagining things, and a growing number of oncologists are rushing to offer remedies, including stimulants commonly used for attention-deficit disorder and acupuncture.

…Virtually all cancer survivors who have had toxic treatments like chemotherapy experience short-term memory loss and difficulty concentrating during and shortly afterward, experts say. But a vast majority improve. About 15 percent, or roughly 360,000 of the nation’s 2.4 million female breast cancer survivors, the group that has dominated research on cognitive side effects, remain distracted years later, according to some experts. And nobody knows what distinguishes this 15 percent.

… The central puzzle of chemo brain is that many of the symptoms can occur for reasons other than chemotherapy.

Abrupt menopause, which often follows treatment, also leaves many women fuzzy-headed in a more extreme way than natural menopause, which unfolds slowly. Those cognitive issues are also features of depression and anxiety, which often accompany a cancer diagnosis. Similar effects are also caused by medications for nausea and pain.

…’So many factors affect cognitive function, and the kinds of cognitive problems associated with cancer treatment can be caused by many other things than chemotherapy…’ ” (New York Times )

Chemotherapy Fog Is No Longer Ignored as Illusion

“Chemo brain is part of the language now… [A]ttitudes are changing as a result of a flurry of research and new attention to the after-effects of life-saving treatment. There is now widespread acknowledgment that patients with cognitive symptoms are not imagining things, and a growing number of oncologists are rushing to offer remedies, including stimulants commonly used for attention-deficit disorder and acupuncture.

…Virtually all cancer survivors who have had toxic treatments like chemotherapy experience short-term memory loss and difficulty concentrating during and shortly afterward, experts say. But a vast majority improve. About 15 percent, or roughly 360,000 of the nation’s 2.4 million female breast cancer survivors, the group that has dominated research on cognitive side effects, remain distracted years later, according to some experts. And nobody knows what distinguishes this 15 percent.

… The central puzzle of chemo brain is that many of the symptoms can occur for reasons other than chemotherapy.

Abrupt menopause, which often follows treatment, also leaves many women fuzzy-headed in a more extreme way than natural menopause, which unfolds slowly. Those cognitive issues are also features of depression and anxiety, which often accompany a cancer diagnosis. Similar effects are also caused by medications for nausea and pain.

…’So many factors affect cognitive function, and the kinds of cognitive problems associated with cancer treatment can be caused by many other things than chemotherapy…’ ” (New York Times )

All systems go for Hawking

“A jet carrying astrophysicist Stephen Hawking took off yesterday from the Kennedy Space Center on a flight to simulate zero gravity and make Hawking the first disabled person to experience weightlessness. …’As you can imagine, I’m very excited,’ Hawking told reporters before the flight. ‘I have been wheelchair-bound for almost four decades. The chance to float free in zero-g will be wonderful.'” (The Calgary Sun)

Lamest Technology Mascots Ever

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“Creatures such as Tux the penguin have become bizarrely treasured icons, while others, such as recent roadside-autopsy subject Jeeves, are better off in the hereafter. And some, such as the freakishly terrifying jester touting Adobe’s new Creative Suite 3, are an indication that vector-based illustration software should probably come with consumer warning labels, just like those found on drugs, circular saws and guns. From the charmingly pixelated to the hideously misguided, join us on a tour of the good, the bad and the ridiculously lame of technology mascots.” (Wired)

Extrasolar planet may be able to support life

“European astronomers say they have found the first Earth-sized planet beyond this solar system with temperatures mild enough to allow liquid water — a crucial step toward answering whether our cradle of life is unique in the universe.

The planet circles the star Gliese 581, which at 20 light years away is among the 100 stars closest to Earth. Dubbed Gliese 581c, the planet orbits very close to its star — closer than Mercury is to our sun. But astronomers with the European Southern Observatory say the star is dim enough that average temperatures on the planet would fall in the range of an ordinary Chicago spring day.

Click here to find out more!
If the planet has water — a big unknown — its size and climate could make it habitable, experts said. The planet appears to be about 50 percent larger than Earth and has five times more mass, making it one of the smallest far-off planets ever detected.

The conditions look promising enough that officials with the California-based SETI Institute, which looks for signs of radio communication from alien civilizations, said they hope to give the planet a fresh look this summer. Previous radio observations of Gliese 581 in the 1990s turned up nothing unusual.” (Orlando Sentinel )

Support of Gonzales affirms power play

Boston Globe news analysis: “Since so much depends on favorable rulings from Justice, the administration can’t possibly look forward to having to justify its actions to a new team of lawyers. But that’s almost certain to happen if Gonzales is replaced by someone outside Bush’s inner circle. Bush would be very hard-pressed to get an inner-circle appointee confirmed by Democratic-controlled Senate. He or she would have had to withstand days of public grilling by Democratic senators, who would try to raise the curtain on any of the administration’s secret programs.

More likely, Bush would be obliged to choose an attorney general with a reputation for independence, such as a former Republican senator with credibility on Capitol Hill. But such a figure would almost certainly be more skeptical of the administration’s assertions of executive power than Gonzales, a close Bush associate from the president’s Texas days.”

Executed in US may be awake as they suffocate

“Some prisoners executed by lethal injection in the United States may die of suffocation while they are still conscious and in pain, University of Miami researchers said in a study that concluded the drugs do not work as intended.

The study, published in the Public Library of Science journal PLoS Medicine, raised new questions about whether the lethal cocktail violates the US constitutional ban on cruel and unusual punishment.” (Stuff.NZ)

Singer’s toilet paper musings leave Rove untouched

Sheryl Crow attempts to debate carbon credits: “As he turned to leave, Crow reached out to touch his arm. ‘Karl swung around and spat, ‘Don’t touch me’,’ recounted Crow and fellow eco-celebrity Laurie David in another blog.

‘How hardened and removed from reality must a person be to refuse to be touched by Sheryl Crow?’

But the singer was not deterred. ‘You can’t speak to us like that, you work for us,’ she thundered to the departing Mr Rove, who responded, ‘I don’t work for you, I work for the American people.’

‘We are the American people,’ the singer shot back.” (Guardian.UK)

Hallelujah Indeed

Debating Handel’s Anti-Semitism: “Scholars have too little investigated questions of religious meaning in Handel’s ‘Messiah,’ particularly the work’s manifest theological anti-Judaism. Previously unknown historical sources for the work’s libretto compiled and arranged by Charles Jennens (1700-73) reveal the text’s implicit designs against Jewish religion. Handel’s musical setting powerfully underscores these tendencies of Jennens’s libretto and adds to them, reaching a euphoric climax in the ‘Hallelujah’ chorus.” — Michael Marissen at the American Handel Festival (New York Times )

Alcohol damages women’s brains faster than men’s

“The brain-damaging effects of alcohol strike women more quickly than men, a new study conducted in Russia confirms.

Female alcoholics performed worse on a number of tests of neurocognitive function compared with males, Dr. Barbara Flannery from RTI International in Baltimore and her colleagues found.

However, Flannery cautioned in an interview with Reuters Health, the findings aren’t good news for alcohol-dependent men. ‘Women are vulnerable to the extent to which they will experience the negative consequences of alcohol abuse and alcoholism more rapidly than men, but men will also experience it — the same kinds of effects,’ she said.

Other physiological effects of alcoholism, such as heart and liver damage, are known to occur more quickly in women than in men, a phenomenon known as ‘telescoping,’ Flannery and her team note in ournal Alcoholism: Clinical and Experimental Research.” (Yahoo! News)

San Francisco Doctors want Pap test for gay men

“The goal is to push back rising rates of anal cancer, a preventable disease that has increased 37 percent in the United States since a decade ago, when the total number of cancer cases increased only 1 percent.

Anal Pap smears would help doctors spot precancerous lesions and wipe them out before they have a chance to turn malignant, say supporters of widespread use of the exam among gay men. But nationwide, doctors have been reluctant to embrace the screening test, partly because there is disagreement over whether it’s effective or even necessary.” (SF Chronicle)

After Suicide, a Window on a Patient’s Other Self

A psychiatrist encounters her patient on MySpace after his death: “I had thought of him as struggling under the constant hold of hallucinations. But he had ignored his hallucinations long enough to write of a different yet equally true self here, and he had found friends who identified him not by psychiatric symptoms but by astrological sign. In this world, he was a Pisces, not a schizophrenic.” — Elissa Ely (New York Times )

Blogger and Podcaster

Are you an “aspiring new media titan”, as the cover says? Then this is the periodical for you! First issue of Blogger and Podcaster magazine. So “blogging” (as you know, I have always eschewed the term and insisted on calling this a weblog) has made it so big it has its own slick new ‘old media’-style rag. For better or worse, it seems to make its appeal to everything FmH is not. However, the user interface is interesting. Click on the upper right corner of the page to turn the page (‘old media’ style).

‘Devastating’ Moyers Probe of Press and Iraq Coming

“The most powerful indictment of the news media for falling down in its duties in the run-up to the war in Iraq will appear next Wednesday, a 90-minute PBS broadcast called ‘Buying the War,’ which marks the return of ‘Bill Moyers Journal.’ E&P was sent a preview DVD and a draft transcript for the program this week.

While much of the evidence of the media’s role as cheerleaders for the war presented here is not new, it is skillfully assembled, with many fresh quotes from interviews (with the likes of Tim Russert and Walter Pincus) along with numerous embarrassing examples of past statements by journalists and pundits that proved grossly misleading or wrong. Several prominent media figures, prodded by Moyers, admit the media failed miserably, though few take personal responsibility. ” (Editor and Publisher thanks to Micheline)

Kucinich to launch Cheney impeachment push on April 25

“Rep. Dennis Kucinich (D-OH), the former mayor of Cleveland who is seeking the 2008 Democratic nomination for president for the second time, has selected a date to introduce articles of impeachment against Vice President Dick Cheney.

A source who asked to remain anonymous told RAW STORY that the articles of impeachment would be introduced next week.” (Raw Story )

This may be seen as an audacious grandstanding move by Kucinich, with his indefatiguable Presidential aspirations. On the other hand, if successful it would remove the major stumbling block to the impeachment of George Bush.

Got nicotine?

Madam Fathom is the pseudonym of a neuroscience PhD student with a weblog about her (I assume it’s a her) field. This is an interesting post about the potential benefits of nicotine that offers a particularly lucid picture of brain function.

“There is a large body of research showing that nicotine, the ingredient that drives people to addiction, improves cognitive function in humans and laboratory animals. The most robust effect demonstrated in human smokers is an enhanced ability to sustain attention to a task for a prolonged period of time, an ability inextricably linked to learning and memory. Of course, learning and memory involve a number of processes (acquisition, encoding, storage, and retrieval), but the ability to concentrate on particular stimuli and screen out the rest is critical for the success of this operation.

Nicotine’s beneficial effects on these “higher” cognitive functions have prompted efforts to develop nicotinic treatments for diseases associated with cognitive impairment, such as Alzheimer’s disease, Parkinson’s disease, attention deficit/hyperactivity disorder, and schizophrenia. However, this area of drug development is impeded by the complexity of nicotine’s actions, including the observation that cognitive improvements have only been reliably detected in either smokers or the cognitively impaired. In contrast, nicotine tends to have deleterious effects on cognitive performance in “normal” non-smokers. (Another factor hampering the development of nicotine-based therapies is that they offer pharmaceutical companies little potential for financial gain, as nicotine sources are easy to come by.)…”

Violent, antisocial, beyond redemption?

“Whether you think of them as mad or bad, they are certainly dangerous to know. All societies contain a few extremely violent individuals, who are either psychopaths or have a related severe personality disorder. With no concern about the harm they inflict, little can be done to change their behaviour, psychiatrists say.

Now the UK government is challenging this dogma in the hope of protecting the public from these highly risky people. It has already altered criminal law to allow certain violent offenders to be given indefinite jail sentences. Over the coming weeks, parliament will debate legislation that could broaden the definition of mental disorders and increase existing powers to detain such people for treatment ” (New Scientist)

Benefits of Antidepressants Outweigh Risk of Suicidal Behavior in Adolescents

A new analysis adds to the evidence that antidepressants are effective in young people, prompting some to renew questions about a ‘black box’ warning required on the drugs since 2004.

The most comprehensive survey yet finds that the benefits of antidepressants outweigh the risks in children and teens during the first few months of treatment. The finding comes three years after the Food and Drug Administration (FDA) ordered pharmaceutical companies to put black warning labels—the strongest possible—on antidepressants cautioning that the drugs may increase the risk of suicidal behavior in kids.” (Scientific American)

The Question Mark in Harper Hall

“He seemed to be crying behind his sunglasses.. It was like talking to a hole sometimes…. Everything emptied out and seemed very dark when he entered.”

Nikki Giovanni, the feminist poet and teacher at Virginia Tech who stirred the campus convocation yesterday with a poem, had Cho in a poetry class two years ago — and it wasn’t long before she had him tossed out. “There was something mean about this boy,” she said. “Troubled kids get drunk and jump off buildings. It was the meanness that bothered me.” Giovanni recalled that Cho came to class in dark sunglasses and a hat. And every day, from very early in the semester, she would ask him to remove the one and then the other. “We would have this sort of ritual,” she said.

Giovanni recalled that Cho “was very intimidating to my other students.” Eventually, other kids began skipping class because of his behavior. The poet then wrote creative writing department boss Lucinda Roy a letter — in part to create a record — asking Roy to remove him from class. Giovanni said Cho turned in material that wasn’t poetry but just junk. “He was writing weird things,” she recalled. “It was terrible…. It was just intimidating.” (Time)

Bolton: US has no obligation to post-invasion Iraq

Andrew Sullivan comments on a BBC interview with John Bolton: “The BBC’s interviewers are not as deferent as some in America. Paxman is among the most aggressive. What staggers me about this clip is Bolton’s point-blank view that the US had no responsibility to impose order after the invasion, and no responsibility for security within the country. Bolton actually says that the only error Bush really made was not giving the Iraqis ‘a copy of the Federalist papers and saying, ‘Good luck.” Yes, he says he’s exaggerating for effect, but he is conveying the gist of the policy. The casual recklessness and arrogance of these people never cease to amaze. The world is theirs’ to play with – and the victims of predictable and predicted violence are left to help themselves.”

Are mobile phones wiping out our bees?

“It seems like the plot of a particularly far-fetched horror film. But some scientists suggest that our love of the mobile phone could cause massive food shortages, as the world’s harvests fail.

They are putting forward the theory that radiation given off by mobile phones and other hi-tech gadgets is a possible answer to one of the more bizarre mysteries ever to happen in the natural world – the abrupt disappearance of the bees that pollinate crops. Late last week, some bee-keepers claimed that the phenomenon – which started in the US, then spread to continental Europe – was beginning to hit Britain as well.

The theory is that radiation from mobile phones interferes with bees’ navigation systems, preventing the famously homeloving species from finding their way back to their hives. Improbable as it may seem, there is now evidence to back this up.” (Independent.UK)

There and Back Again

“Last year, Midas, the muffler company, in honor of its fiftieth anniversary, gave an award for America’s longest commute to an engineer at Cisco Systems, in California, who travels three hundred and seventy-two miles—seven hours—a day, from the Sierra foothills to San Jose and back. “It’s actually exhilarating,” the man said of his morning drive.” (New Yorker)

There and Back Again

“Last year, Midas, the muffler company, in honor of its fiftieth anniversary, gave an award for America’s longest commute to an engineer at Cisco Systems, in California, who travels three hundred and seventy-two miles—seven hours—a day, from the Sierra foothills to San Jose and back. “It’s actually exhilarating,” the man said of his morning drive.” (New Yorker)

The Heroic Imagination

Edge interview with Philip Zimbardo, designer of the (in)famous Stanford Prison Experiment:

“As a social psychologist, I bring forth the power of situations to transform good people into evil, which is what I’ve been studying since my Stanford prison study way back in 1971. I argue that there are some features of special situations that can corrupt the best and brightest. Normal people, even good people. Not all, but most. And the ones who resist, the ones who somehow have the street-smarts – the situational sophistication – to resist are the exceptions. In fact, I’m going to call them heroes.

…My research really says several things. One, that we have to recognize that some situations, some social settings, some behavioral contexts, have an unrecognized power to transform the human character of most of us. Two, that the way to resist – the way to prevent a descent into Hell, if you will – is precisely by understanding what it is about those situations that gives them transformative power. It is by this understanding that you can change those situations, avoid those situations, challenge those situations. And it’s only by willfully ignoring them, by assuming individual nobility, individual rationality, or individual morality that we become most vulnerable to their insidious power to make good people do bad things. Those who sustain an illusion of invulnerability are the easiest touch for the con man, the cult recruiter, or the social psychologist ready to demonstrate who easy it is to twist such arrogance into submission.

One way of looking at the consequences of the Stanford Prison Study is as a cautionary tale of the many ways in which good people can be readily and easily seduced into evil. But there’s an equally important – maybe more important – consequence of the study, which is what it tells us about the flip side of human nature. The Stanford Prison Study was ended abruptly: it was supposed to run for two weeks and it ended – was terminated – after only six days because of a very heroic act…”

Zimbardo reveals that he ended the experiment because of the abhorrence his girlfriend, now his wife, expressed when she came down to observe. Zimbardo turns Hannah Arendt’s phrase on its head, talking about the “banality of heroism”:

“Most people in the world who engage in heroic acts are …individuals who find themselves in a particular situation – one in which other people are looking the other way or continuing to perpetrate an evil behavior – and who, for some reason we don’t know, take heroic action. They do something to stop it – blow the whistle or otherwise challenge it in a direct way. That action is “heroic,” even if the people are “ordinary.” My sense is that the typical notion we have of heroes as super-stars, as super heroes, as Superman, and Batman, and Wonder Woman, gives us a false impression that being a hero means being able to do thing that none of us can actually accomplish. I want to argue just the opposite: that what we have to be doing more and more is cultivating the “heroic imagination” – especially in our children.”

Zimbardo’s notion of a hero has alot to do with activism, empowering people to speak truth to powerful wrongdoing, both by “cultivating the heroic imagination” in individuals, largely through education, and by changing our institutions so they become “hero-engendering.” He calls for “a new revolution of making heroes more common”. Nothing really new in this except the phraseology; it has been the eternal preoccupation of social critics and revolutionaries. But how to get there…

Shell Shocked

A Shock Wave of Brain Injuries: “IEDs have added a new dimension to battlefield injuries: wounds and even deaths among troops who have no external signs of trauma but whose brains have been severely damaged. Iraq has brought back one of the worst afflictions of World War I trench warfare: shell shock. The brain of a soldier exposed to a roadside bomb is shocked, truly.

About 1,800 U.S. troops, according to the Department of Veterans Affairs, are now suffering from traumatic brain injuries (TBIs) caused by penetrating wounds. But neurologists worry that hundreds of thousands more — at least 30 percent of the troops who’ve engaged in active combat for four months or longer in Iraq and Afghanistan — are at risk of potentially disabling neurological disorders from the blast waves of IEDs and mortars, all without suffering a scratch.

For the first time, the U.S. military is treating more head injuries than chest or abdominal wounds, and it is ill-equipped to do so. According to a July 2005 estimate from Walter Reed Army Medical Center, two-thirds of all soldiers wounded in Iraq who don’t immediately return to duty have traumatic brain injuries.” (Washington Post 4/6/07)

Better Than Netflix!

DailyLit: Read books by email. “…[If] you are like us, you spend hours each day reading email but don’t find the time to read books. DailyLit brings books right into your inbox in convenient small messages that take less than 5 minutes to read. This works incredibly well not just on your computer but also on a Treo, Blackberry, Sidekick or whatever the PDA of your choice. In the words of Dr. Seuss: Try it, you might like it! ” [thanks, abby]

? I recall once I subscribed to email serialization of Finnegans Wake, but the mailing list died. I just checked; dailylit doesn’t have that, but they have everything else of Joyce’s. I might start with William James’ Varieties of Religious Experience, Henry James’ Turn of the Screw, or Boswell’s Life of Johnson, and that’s just from the ‘J’ page…

Autologous hematopoietic stem cell transplantation

Treatment shows promise against diabetes: “Thirteen young diabetics in Brazil have ditched their insulin shots and need no other medication thanks to a risky, but promising treatment with their own stem cells – apparently the first time such a feat has been accomplished.” (Seattle Post-Intelligencer)

Some of the recipients have been insulin-free for as long as three years, although the researchers do not claim this is a cure.

Plus Ca Change?

“On the surface, recent votes in Congress appear to signal a new Democratic determination to withdraw from Iraq. But the reality is otherwise. It is not only that the resolutions were drafted and adopted with the certain knowledge that they would be vetoed. More important, even if a future Democratic president did try to implement the new plans, the results would likely end up looking oddly similar to the Bush administration’s current strategy. In politics as in war, things are seldom what they seem.” — Noah Feldman (New York Times Magazine)

Depression or Just a Little Emotional Blow?

Many Diagnoses of Depression May Be Misguided, Study Says: “About one in four people who appear to be depressed are in fact struggling with the normal mental fallout from a recent emotional blow, like a ruptured marriage, the loss of a job or the collapse of an investment, a new study suggests. To avoid unnecessary diagnoses and stigma, the standard definition of depression should be redrawn to specifically exclude such cases, the authors argue.

The study, appearing today in The Archives of General Psychiatry, is based on survey data from more than 8,000 Americans; it did not analyze the number of people who had been misdiagnosed.

Psychiatrists and other doctors who take careful medical histories do so precisely to rule out such life blows, as well as the effects of physical illnesses, before making a diagnosis of depression.

But the American Psychiatric Association’s diagnostic manual does not specifically exclude people experiencing deep but normal feelings of sadness, unless they are bereaved by the death of a loved one. And an increasing number of school districts and health clinics use simple depression checklists, which do not take context into account, the authors said.” (New York Times )

The study compared 157 bereaved individuals and 710 who met the criteria for major depressive disorder whose episode had been triggered by another loss. Grief specifically precludes a diagnosis of major depression, but the investigators showed that those diagnosed with depression after other losses did not differ significantly from the bereavement group on a well-chosen spectrum of indicators of the severity and impact of their symptoms. They concluded that the data “do not support the validity of uniquely excluding uncomplicated bereavement but not uncomplicated reactions to other losses” from the diagnosis of major depressive disorder.

The researchers are a social worker, two sociologists and one psychiatrist — interestingly, a psychiatric epistemologist who participated in the formulation of the latest version of the Diagnostic and Statistical Manual (DSM-4), the official ‘bible’ of acceptable psychiatric diagnoses and their defining criteria. This should be a clue that the study should be interpreted in light of the perennial conflict within mental health care between the medical and social models; it is a shot across the bow aimed at biological psychiatry. When psychoanalysts dominated in shaping the psychiatric paradigms of diagnosis and treatment in the era before modern psychopharmacology, a crucial distinction was made between “endogenous” and “reactive” depression. One still hears vestiges of that outlook when healthcare personnel observe, “Wouldn’t you be depressed too if you had gone through what he/she did?”

With the ascendency of biological models and medication-based treatment, roughly since the ’60’s, however, the distinction was largely thrown out (with the exception of the exclusion for acute grief), and a generation of psychiatrists were trained to see it as quaint and archaic. The focus in diagnosing and treating has come more and more to be on the description, the symptoms, of an episode of emotional distress (such as can be captured in the symptom checklists the article mentions) to the exclusion of the meaning of that distress to the individual and its contextualization in an individual life. With the development of medications that can treat depressive symptoms, what has been lost has been the question of whether they should be treated in all instances. Recent dogma emphasizing that depressive episodes not be seen as self-contained but as manifestations of a lifelong relapsing condition mitigates for preventive treatment through indefinite antidepressant maintenance. Relapses are explained with disdain as the result of inadequately insightful patients failing to comply with that paradigm. I will leave it to my readers to draw their own conclusions as to whether this deserves to be seen as an aspect of the medicalization of everyday life driven by market pressures and the selling of healthcare down the river by the unholy alliance of Big Pharma and its handmaiden physicians.

On the other hand, I quibble with the implication of the article that this finding points to wholesale “misdiagnosis” of depression where it is unwarranted. That would be too simple, and I doubt it is what the authors intended. What is at stake is not just tidying up diagnostic criteria or diagnostic practices. There is no “true” definition of what depression is to aim for; it is a social construction that reflects dominant values and assumptions. We are in the midst of a full-fledged clash of conflicting paradigms, with a study such as this at its nidus. As Kuhn suggested in The Structure of Scientific Revolutions , evidence inconsistent with the dominant paradigm is explained away or ignored until a sufficient accumulation occurs.

What are the dangers of ignoring these challenges to the dominant conception of depression, markedly broadened from that of a generation ago and ignoring context almost entirely? One of our real social ills may be not the prevalence of depression but of the narcissistic expectation that we are entitled to have any depressive distress eradicated, and the parallel assumption that it is the fault of a ‘chemical imbalance’ rather than the way we make sense of the world, process our feelings or treat one another. What is at stake is something very basic about the parameters of the social construction of the self in modern society. There may be biological consequences as well. I have been troubled by the possibility — which I cannot get many of my colleagues to take seriously — that having too low a threshold for beginning or maintaining our patients on antidepressants may actually perpetuate or worsen depressive dysfunction of the brain. Although antidepressants are not, in a rigid sense, addictive, their use may cause a self-perpetuating necessity to continue to use them. I hope to have more to say about that in the future as I clarify and extend my thinking about this issue.

Depression or Just a Little Emotional Blow?

Many Diagnoses of Depression May Be Misguided, Study Says: “About one in four people who appear to be depressed are in fact struggling with the normal mental fallout from a recent emotional blow, like a ruptured marriage, the loss of a job or the collapse of an investment, a new study suggests. To avoid unnecessary diagnoses and stigma, the standard definition of depression should be redrawn to specifically exclude such cases, the authors argue.

The study, appearing today in The Archives of General Psychiatry, is based on survey data from more than 8,000 Americans; it did not analyze the number of people who had been misdiagnosed.

Psychiatrists and other doctors who take careful medical histories do so precisely to rule out such life blows, as well as the effects of physical illnesses, before making a diagnosis of depression.

But the American Psychiatric Association’s diagnostic manual does not specifically exclude people experiencing deep but normal feelings of sadness, unless they are bereaved by the death of a loved one. And an increasing number of school districts and health clinics use simple depression checklists, which do not take context into account, the authors said.” (New York Times )

The study compared 157 bereaved individuals and 710 who met the criteria for major depressive disorder whose episode had been triggered by another loss. Grief specifically precludes a diagnosis of major depression, but the investigators showed that those diagnosed with depression after other losses did not differ significantly from the bereavement group on a well-chosen spectrum of indicators of the severity and impact of their symptoms. They concluded that the data “do not support the validity of uniquely excluding uncomplicated bereavement but not uncomplicated reactions to other losses” from the diagnosis of major depressive disorder.

The researchers are a social worker, two sociologists and one psychiatrist — interestingly, a psychiatric epistemologist who participated in the formulation of the latest version of the Diagnostic and Statistical Manual (DSM-4), the official ‘bible’ of acceptable psychiatric diagnoses and their defining criteria. This should be a clue that the study should be interpreted in light of the perennial conflict within mental health care between the medical and social models; it is a shot across the bow aimed at biological psychiatry. When psychoanalysts dominated in shaping the psychiatric paradigms of diagnosis and treatment in the era before modern psychopharmacology, a crucial distinction was made between “endogenous” and “reactive” depression. One still hears vestiges of that outlook when healthcare personnel observe, “Wouldn’t you be depressed too if you had gone through what he/she did?”

With the ascendency of biological models and medication-based treatment, roughly since the ’60’s, however, the distinction was largely thrown out (with the exception of the exclusion for acute grief), and a generation of psychiatrists were trained to see it as quaint and archaic. The focus in diagnosing and treating has come more and more to be on the description, the symptoms, of an episode of emotional distress (such as can be captured in the symptom checklists the article mentions) to the exclusion of the meaning of that distress to the individual and its contextualization in an individual life. With the development of medications that can treat depressive symptoms, what has been lost has been the question of whether they should be treated in all instances. Recent dogma emphasizing that depressive episodes not be seen as self-contained but as manifestations of a lifelong relapsing condition mitigates for preventive treatment through indefinite antidepressant maintenance. Relapses are explained with disdain as the result of inadequately insightful patients failing to comply with that paradigm. I will leave it to my readers to draw their own conclusions as to whether this deserves to be seen as an aspect of the medicalization of everyday life driven by market pressures and the selling of healthcare down the river by the unholy alliance of Big Pharma and its handmaiden physicians.

On the other hand, I quibble with the implication of the article that this finding points to wholesale “misdiagnosis” of depression where it is unwarranted. That would be too simple, and I doubt it is what the authors intended. What is at stake is not just tidying up diagnostic criteria or diagnostic practices. There is no “true” definition of what depression is to aim for; it is a social construction that reflects dominant values and assumptions. We are in the midst of a full-fledged clash of conflicting paradigms, with a study such as this at its nidus. As Kuhn suggested in The Structure of Scientific Revolutions , evidence inconsistent with the dominant paradigm is explained away or ignored until a sufficient accumulation occurs.

What are the dangers of ignoring these challenges to the dominant conception of depression, markedly broadened from that of a generation ago and ignoring context almost entirely? One of our real social ills may be not the prevalence of depression but of the narcissistic expectation that we are entitled to have any depressive distress eradicated, and the parallel assumption that it is the fault of a ‘chemical imbalance’ rather than the way we make sense of the world, process our feelings or treat one another. What is at stake is something very basic about the parameters of the social construction of the self in modern society. There may be biological consequences as well. I have been troubled by the possibility — which I cannot get many of my colleagues to take seriously — that having too low a threshold for beginning or maintaining our patients on antidepressants may actually perpetuate or worsen depressive dysfunction of the brain. Although antidepressants are not, in a rigid sense, addictive, their use may cause a self-perpetuating necessity to continue to use them. I hope to have more to say about that in the future as I clarify and extend my thinking about this issue.

Will Vermont Secede from the Union?

“The winds of secession are blowing in the Green Mountain State. Vermont was once an independent republic, and it can be one again. We think the time to make that happen is now. Over the past 50 years, the U.S. government has grown too big, too corrupt and too aggressive toward the world, toward its own citizens and toward local democratic institutions. It has abandoned the democratic vision of its founders and eroded Americans’ fundamental freedoms.” (Washington Post via Alternet)

Will Vermont Secede from the Union?

“The winds of secession are blowing in the Green Mountain State. Vermont was once an independent republic, and it can be one again. We think the time to make that happen is now. Over the past 50 years, the U.S. government has grown too big, too corrupt and too aggressive toward the world, toward its own citizens and toward local democratic institutions. It has abandoned the democratic vision of its founders and eroded Americans’ fundamental freedoms.” (Washington Post via Alternet)

AugCog

Augmented Cognition International Society: “Limitations in human cognition are due to intrinsic restrictions in the number of mental tasks that a person can execute at one time, and this capacity itself may fluctuate from moment to moment depending on a host of factors including mental fatigue, novelty, boredom and stress. As computational interfaces have become more prevalent in society and increasingly complex with regard to the volume and type of information presented, researchers have investigated novel ways to detect these bottlenecks and have devised and continue to determine strategies to aid users and improve their performance by effectively accommodating capabilities and limitations in human information processing and decision making.

A main goal of the field of Augmented Cognition (AugCog) is to research and develop technologies capable of extending, by an order of magnitude or more, the information management capacity of individuals working with 21st Century computing technologies.”