Madam Fathom is the pseudonym of a neuroscience PhD student with a weblog about her (I assume it’s a her) field. This is an interesting post about the potential benefits of nicotine that offers a particularly lucid picture of brain function.
Nicotine’s beneficial effects on these “higher” cognitive functions have prompted efforts to develop nicotinic treatments for diseases associated with cognitive impairment, such as Alzheimer’s disease, Parkinson’s disease, attention deficit/hyperactivity disorder, and schizophrenia. However, this area of drug development is impeded by the complexity of nicotine’s actions, including the observation that cognitive improvements have only been reliably detected in either smokers or the cognitively impaired. In contrast, nicotine tends to have deleterious effects on cognitive performance in “normal” non-smokers. (Another factor hampering the development of nicotine-based therapies is that they offer pharmaceutical companies little potential for financial gain, as nicotine sources are easy to come by.)…”