Via VICE:

‘Longevity maxxing is having a moment. Biological age tests, NAD+ supplements, Bryan Johnson’s entire existence—the premise is that aging is a problem with a solution. A new study suggests the solution has a ceiling nobody’s talking about.

Researchers at the Skolkovo Institute of Science and Technology ran a thought experiment with a deceptively direct premise: if every reversible aspect of aging could somehow be eliminated—every disease, every hormonal decline, every cellular dysfunction science might one day fix—what would actually kill us? Their answer, published in npj Aging, is random DNA mutations. The kind that accumulate in cells throughout a lifetime, mostly harmless, occasionally not, and ultimately unavoidable.

The team built a mathematical model to calculate how much damage these so-called somatic mutations would do to a population that had otherwise beaten aging. Their analysis found that even with all other reversible aging hallmarks removed, somatic mutations alone limit median human lifespan to somewhere between 146 and 194 years—about double current longevity. A theoretical ceiling, not a prediction….’