Mike Pence transitions from Trump’s dull sidekick to Republican pariah

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‘According to a recent article in The Atlantic, Pence is facing a significant lack of support among Republican voters in his ambitions to become the next President of the United States. And who can blame them? Showing loyalty to a narcissistic dictator is a viable career strategy for GOP politicians. But because Pence didn’t do his former boss’s bidding by overturning the election results and instantly transforming the United States into an autocratic dystopia, 97% of Republicans suspect him of being a Soros-funded RINO antifa communist….’

— via Boing Boing

Mouse study: time-restricted eating reshapes gene expression throughout the body

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‘The findings, published in Cell Metabolism, have implications for a wide range of health conditions where time-restricted eating has shown potential benefits, including diabetes, heart disease, hypertension, and cancer.

“We found that there is a system-wide, molecular impact of time-restricted eating in mice,” says Professor Satchidananda Panda, senior author and holder of the Rita and Richard Atkinson Chair at Salk. “Our results open the door for looking more closely at how this nutritional intervention activates genes involved in specific diseases, such as cancer.”

For the study, two groups of mice were fed the same high-calorie diet. One group was given free access to the food. The other group was restricted to eating within a feeding window of nine hours each day. After seven weeks, tissue samples were collected from 22 organ groups and the brain at different times of the day or night and analyzed for genetic changes. Samples included tissues from the liver, stomach, lungs, heart, adrenal gland, hypothalamus, different parts of the kidney and intestine, and different areas of the brain.

The authors found that 70 percent of mouse genes respond to time-restricted eating.

“By changing the timing of food, we were able to change the gene expression not just in the gut or in the liver, but also in thousands of genes in the brain,” says Panda.

Nearly 40 percent of genes in the adrenal gland, hypothalamus, and pancreas were affected by time-restricted eating. These organs are important for hormonal regulation. Hormones coordinate functions in different parts of the body and brain, and hormonal imbalance is implicated in many diseases from diabetes to stress disorders. The results offer guidance to how time-restricted eating may help manage these diseases….’

— via Neuroscience Stuff tumbler

Is ChatGPT Closer to a Human Librarian Than It Is to Google?

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‘A search engine researcher explains the promise and peril of letting ChatGPT and its cousins search the web for you….’

— via Gizmodo

Be aware that large language model systems are just using a mechanism to connect words and generate seemingly intelligent responses. These systems lack a true understanding of the meaning of words and often produce parroted statements based on patterns of words found in context. This limitation can cause the system to generate false or inaccurate responses, also known as “hallucinating” answers.