‘As infections caused by the Omicron variant surge across the world, countries may soon face the difficult choice of either imposing strict lockdowns or letting the variant run through the population. Vaccinations are reducing the severity of the disease but are ineffective in halting the spread of the highly transmissible infection. As vaccine companies rush to develop variant-specific booster doses that might become the norm in this pandemic that will soon enter its third calendar year, the news of a single vaccine that can last a lifetime is highly welcome.
The vaccine that is being developed by Michinori Kohara and his team of researchers employs the most successful vaccine used in history, one against smallpox. The team uses a strain of the vaccinia virus that does not cause disease but replaced some of its protein components with those from the SARS-CoV-2 spike protein.
While recombining the spike protein with a different delivery mechanism is a common strategy used in vaccine design these days, Kohara is confident that his vaccine can not only deliver potent neutralizing antibodies with a single dose, they also induce strong cellular immunity that offers long term protection.— via Interesting Engineering