The morbidity and mortality of sleep deprivation has long been recognized. A new study in the journal Cell by researchers from the Harvard Medical School finds that some of the damage may be mediated by an unexpected culprit — oxidative stress caused by a buildup of the molecules called reactive oxygen species (ROS) in the gut. In sleep-deprived fruit flies and mice, at least, the effects can be reversed, even with continuing sleep deprivation, by aggressive use of any of 11 various antioxidants including melatonin, lipoid acid, and NAD. These antioxidants did not extend the lifespan or improve the health of non-sleep deprived control subjects.
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