Long-term Use of Anxiolytics Linked to Alzheimer’s Disease, Study Suggests

Via Psych News Alert: ‘The results, published in BMJ, showed that past use of benzodiazepines for three months or more was associated with an increased risk—up to 51%—for AD. The association increased even more with longer exposure to the anxiolytic. In addition, the use of long-acting forms of benzodiazepines increased risk for AD by 19 percent more than that of the short-acting. Results were sustained after adjusting for anxiety, depression, and sleep disorders.“Benzodiazepines are known to be associated with an increased risk of worsening cognition…even in cognitively normal elderly subjects,” said Davangere Devanand, M.D., director of the geriatric psychiatry program at Columbia University, in an interview with Psychiatric News…’

The researchers, and the reaction to the study, focused on the potential pharmacological basis for the finding. But I have a different thought. There is substantial evidence that maintaining mental agility and stimulation can ward off the development of Alzheimer’s Disease. But chronic anxiolytic medication users are generally chronically anxious and risk-averse, thus probably less prone to continue to challenge themselves mentally.