Alzheimer’s Could Be Diabetes-like Illness, Study Suggests

“That’s the tantalizing suggestion from a new study that finds insulin production in the brain declines as Alzheimer’s disease advances.

‘Insulin disappears early and dramatically in Alzheimer’s disease,’ senior researcher Suzanne M. de la Monte, a neuropathologist at Rhode Island Hospital and a professor of pathology at Brown University Medical School, said in a prepared statement.

‘And many of the unexplained features of Alzheimer’s, such as cell death and tangles in the brain, appear to be linked to abnormalities in insulin signaling. This demonstrates that the disease is most likely a neuroendocrine disorder, or another type of diabetes,’ she added.

The discovery that the brain produces insulin at all is a recent one, and de la Monte’s group also found that brain insulin produced by patients with Alzheimer’s disease tends to fall below normal levels.

Now her group has discovered that brain levels of insulin and its related cellular receptors fall precipitously during the early stages of Alzheimer’s. Insulin levels continue to drop progressively as the disease becomes more severe — adding to evidence that Alzheimer’s might be a new form of diabetes, she said.

In addition, the Brown University team found that low levels of acetylcholine — a hallmark of Alzheimer’s — are directly linked to this loss of insulin and insulin-like growth factor function in the brain.” (Yahoo! News)

I have just heard anecdotal preliminary reports from research a psychiatrist friend of mine is doing suggesting that “insulin-sensitizing” medications improve cognitive functions in Alzheimer’s patients regardless of whether they have peripheral diabetes or not. A larger study is underway.

Dalai Lama Gets Meditation Lesson

Seems like a Western-centric headline from Wired:

“Scientists present at this month’s meeting included Richard Davidson, a Harvard University-trained neuroscientist who has done pioneering research on Buddhist monks, and Robert Sapolsky, a Stanford University professor who studies the effects of stress on the body. They told the Dalai Lama, winner of the Nobel Peace Prize, and an audience of 2,500 about recent experiments showing meditation can strengthen the immune system, prevent relapse in people with depression and lower cortisol levels. Cortisol is a hormone associated with stress.

…[But] while Western researchers are exploring the effects of meditation on physical health, Alan Wallace, a leading Tibetan scholar and one of the Dalai Lama’s translators, pointed out that when faced with physical ailments, Tibetans traditionally turned to doctors or healers, not to meditation.

The purpose of meditation, added the Dalai Lama, is not to cure physical ailments, but to free people from emotional suffering.”

When the Doctor Is in…

…but You Wish He Wasn’t: “Ms. Wong had come across a bane of the medical profession: the difficult doctor. These doctors may be arrogant or rude, highhanded or dismissive. They drive away patients who need help, and some have been magnets for malpractice claims.

And while such doctors have always been part of medicine, medical organizations say they fear that they are increasingly common – doctors, under pressure to see more patients, are spending less and less time with each one and are replacing long discussions with laboratory tests and scans – and that most problem doctors apparently have no idea of their patients’ opinions of them.” (New York Times )