‘Researchers have discovered that Alzheimer’s disease may be reversible in animal models through a treatment that restores the brain’s metabolic balance. This study, published in the journal Cell Reports Medicine, demonstrates that restoring levels of a specific energy molecule allows the brain to repair damage and recover cognitive function even in advanced stages of the illness. The results suggest that the cognitive decline associated with the condition is not an inevitable permanent state but rather a result of a loss of brain resilience.

For more than a century, people have considered Alzheimer’s disease an irreversible illness. Consequently, research has focused on preventing or slowing it, rather than recovery. Despite billions of dollars spent on decades of research, there has never been a clinical trial of any drug to reverse and recover from the condition. This new research challenges that long held dogma.

…The researchers focused on a molecule called nicotinamide adenine dinucleotide, known as NAD+. This molecule is essential for cellular energy and repair across the entire body. Scientists have observed that NAD+ levels decline naturally as people age, but this loss is much more pronounced in those with neurodegenerative conditions. Without proper levels of this metabolic currency, cells become unable to execute the processes required for proper functioning and survival.…’ (Karina Petrova via PsyPost)