‘Ketamine is recognized as a rapid and sustained antidepressant, particularly for major depression unresponsive to conventional treatments. Anhedonia is a common symptom of depression for which ketamine is highly efficacious, but the underlying circuits and synaptic changes are not well understood. Here, we show that the nucleus accumbens (NAc) is essential for ketamine’s effect in rescuing anhedonia in mice subjected to chronic stress. Specifically, a single exposure to ketamine rescues stress-induced decreased strength of excitatory synapses on NAc-D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs).…’ — via Neuron

‘The latest conspiracy theory running around is that collaborating Murdoch and Vance will execute a 25th Amendment rug pull on the Orange Menace, when the time is “right.”

I guess the Lincoln Project knows what gets under Trump’s skin. Sowing more suspicion that Shady JD is just waiting until he can replace Trump and run for two additional full terms as President.…’ —via Boing Boing