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Finding vaccines to combat drugs of abuse is an ongoing and challenging quest. The goal is to find compounds that produce antibodies that bind to drugs in the bloodstream, stopping them from entering the brain, and thus eliminating their effects. A heroin vaccine is even more difficult to develop because the drug quickly metabolizes into other active compounds. However, researchers from the Scripps Research Institute in La Jolla, Calif., have tested a new approach that that takes heroin metabolism into account.” (Psychiatric News)