The warning follows experiments in rats that were simultaneously exposed to loud noise and MDMA, aka ecstasy. The noise both intensified and prolonged the effects of the drug on the animals’ brains.
Michelangelo Iannone of Italy’s Institute of Neurological Science in Catanzaro and his colleagues gave rats varying doses of MDMA while bombarding them with white noise for 3 hours at the maximum volume permitted in Italian nightclubs.
Those given the highest dose of ecstasy, equivalent to the average amount taken by a partygoer on a night out, experienced a slump in electrical power of the cerebral cortex for up to five days after the noise was switched off. Previous studies suggest that such loss of power is related to brain hyperactivity and can ultimately lead to depression.
Rats on high doses that were not exposed to noise, and those exposed to noise but given lower doses of MDMA, experienced equally large slumps in brain power, but these only lasted for about one day (BMC Neuroscience, DOI :10.1186/1471-2202-7-13).
Since the experiments were in rats, it is hard to work out what the results mean for humans, but they do suggest that we need to know more about how ecstasy users are affected by their environment.” (New Scientist)
