‘Mystery particle’ in schizophrenics

Thanks to Alwin Hawkins, a fellow health professional weblogger, for sending me this blink.

A tiny particle found in the spinal fluid of schizophrenia patients is baffling doctors who cannot work out what it is.

The Swedish researcher involved has even suggested it might be “a new form of life”, although other experts say this is unlikely.

However, it could mean that doctors have a reliable test for schizophrenia.’ BBC

The ‘new form of life’ angle, the more sensationalistic aspect of this news, should be placed in the context of the continuing British preoccupation with BSE (“mad cow disease”), caused by miniscule nonviral, nonbacterial communicable (but by no stretch of the imagination living!) protein particles known as prions. However, I’m among those who find this analogy implausible for schizophrenia, which has none of the epidemiology of an infectious disease. If these mystery particles are real, they are more likely a byproduct than a cause of the pathological process in the schizophrenic brain. And that’s a great big “if” — the history of schizophrenia research is rife with the ‘discovery’ of putative markers for the disease in blood, urine or cerebrospinal fluid which have uniformly turned out to be artifacts. I’d love to read the scientific paper on this finding (from Neuroscience Letters; here’s the abstract

but the full text requires a subscription), rather than rely on the popular press, which does not even indicate if the study was done in a “double blind” fashion.