Secret’s in the Gray Matter. MRI brain scans of subjects with family histories of early-onset Alzheimer’s dementia and who themselves had gene markers predictive of the disease (all of whom went on to develop the disease over eight-year followup) have showed structural deterioration of the medial temporal lobe as much as three years before symptomatic manifestations of the disease developed. It is possible that the medications we now use to retard the progression of symptoms (after the disease appears) might be useful in preventing or delaying its initial emergence in cases that could be identified this early. Wired