More fMRIe (functional magnetic resonance imaging excitement): Location of Sense of Humor Discovered. Activity in a region in the orbital prefrontal cortex correlates with the experience of appreciating a joke or a pun. It makes sense that the arguably uniquely human (cf. for example the 1938 classic Homo Ludens: a study of the play element in culture by historian Johann Huizinga) capacity to appreciate the complex phenomenon of a joke resides in this uniquely human cortical area. Independent